Lineage-specific Induction of B Cell Apoptosis and Altered Signal Transduction by the Phosphotyrosine Phosphatase Inhibitor Bis(maltolato)oxovanadium(IV)
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چکیده
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Induction of apoptosis in human tumor cell lines by platelets
Introduction: It has been reported that platelets can eradicate tumor cells in vitro, although the mechanism of this effect has not been determined. The effect of platelets on the induction of apoptosis in tumor cells is largely unknown. Materials and methods: To investigate this effect, two human hematologic cell lines, K562 and Daudi, were independently faced with unstimulated and thromb...
متن کاملThe Genetics of Signal Transduction and the Feto-Maternal Relationship. A Study of Cytosolic Low Molecular Weight Phosphotyrosine Phosphatase
Intracellular kinases mediate positive signalling from surface receptors by phosphorylating critical target proteins whereas phosphatases inhibit this process. Differential phosphatase activity at the feto-maternal interface could determine the appropriate relative growth and development on each side of the placenta. The highly polymorphic cytosolic low molecular weight phosphotyrosine-phosphat...
متن کاملSynergistic Apoptosis Induction in Leukemic Cells by the Phosphatase Inhibitor Salubrinal and Proteasome Inhibitors
BACKGROUND Cells adapt to endoplasmic reticulum (ER)-stress by arresting global protein synthesis while simultaneously activating specific transcription factors and their downstream targets. These processes are mediated in part by the phosphorylation-dependent inactivation of the translation initiation factor eIF2alpha. Following restoration of homeostasis protein synthesis is resumed when the ...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
Induction of Thyroid Cancer Cell Apoptosis by a Novel Nuclear Factor B Inhibitor, Dehydroxymethylepoxyquinomicin
Purpose: The objective of the study was to determine the effects of a novel selective nuclear factor B (NFB) inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), in thyroid carcinoma cells in vitro and in vivo and to additionally elucidate the molecular mechanisms underlying the action of this chemotherapeutic agent. Experimental Design: In the in vitro experiments, the induction of apoptosis by ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.35.20824